The NFL prohibited teams from distributing smelling salts this season, citing their potential to mask concussions. That hasn't stopped San Francisco 49ers players from using them every game day.

The Niners are missing Nick Bosa, Fred Warner, Brandon Aiyuk, and seemingly countless others. The Cardinals will suit up without Marvin Harrison Jr. and Will Johnson. It sets this game up to be gritty and emotional, but both teams still have plenty of good players and Pro Bowl talents.

The San Francisco 49ers face the Arizona Cardinals in Week 11 of the NFL season on Sunday, Nov. 16, 2025 at State Farm Stadium in Glendale, Arizona.

Without their explosive rookie receiver, the Cardinals' offense faces a significant challenge. The 49ers' battered defense could exploit this crucial void.

USA Today's NFL experts make their picks for a Week 11 showdown between the Arizona Cardinals and San Francisco 49ers

Mac Jones filled in well as the 49ers' starting quarterback while Brock Pirdy has been out, but now he's headed back to the bench.

A r ecent report from Ian Rapaport of NFL Network noted that the 49ers may be willing to entertain trade offers for Jones. Jones is on a modest contract heading into next year with a cap hit just under $4M. It gives the 49ers a lot of leverage.