A case that could weaken the separation of church and state goes before the Supreme Court on Wednesday as the justices consider whether Oklahoma can approve the first-ever religious public charter school.

The U.S. Supreme Court is set on Wednesday to hear arguments in a bid led by two Catholic dioceses to establish in Oklahoma the nation's first taxpayer-funded religious charter school in a major test of religious rights and the separation of church and state in American education.

A high-stakes clash at the US Supreme Court threatens to upend the nation’s charter-school system and further strain an already challenged investment arena.