The 49ers head to State Farm Stadium to face the Arizona Cardinals with Brock Purdy back under center. Purdy was cleared off the injury report and is starting after missing six games with a turf-toe variant.

Oct 6, 2024; Santa Clara, California, USA; San Francisco 49ers tight end George Kittle (85) gestures after a catch against the Arizona Cardinals during the fourth quarter at Levi's Stadium. Mandatory Credit: Darren Yamashita-Imagn Images / Darren Yamashita-Imagn Images

Head coach Kyle Shanahan of the San Francisco 49ers looks on during warmups before the game against the Arizona Cardinals at State Farm Stadium on Nov. 16, 2025 in Glendale, Ariz. A costly penalty by a San Francisco 49ers defensive player led head coach Kyle Shanahan to bench him and confront him on the sidelines.

The San Francisco 49ers open the game with a 98-yard kick return and running back Christian McCaffrey caps off the drive on the first play with a 1-yard rushing touchdown on the road against the Arizona Cardinals in the first 13 seconds of the game.

San Francisco 49ers wide receiver Ricky Pearsall has finally come back from injury but is off to a lackluster start in the Week 11 game against the Arizona Cardinals. Here's a closer look at what's going on.

The San Francisco 49ers entered Sunday in Week 11 with a healthy team, at least in terms of players on the roster. Quarterback Brock Purdy and receiver Ricky Pearsall would return after missing several games.

Call Sunday’s Niners-Cardinals showdown the Battle of Wounded Knee… and Leg, and Shoulder, and Feet, and even Appendixes. You don’t need NFL Next Gen Stats data to break down this game, you need a copy of Gray’s Anatomy and a first-year resident on call.

The Arizona Cardinals and San Francisco 49ers revealed their final inactives report for Week 11 - who's in, who's out?