Head coach Kyle Shanahan of the San Francisco 49ers looks on during warmups before the game against the Arizona Cardinals at State Farm Stadium on Nov. 16, 2025 in Glendale, Ariz. A costly penalty by a San Francisco 49ers defensive player led head coach Kyle Shanahan to bench him and confront him on the sidelines.

Wide receiver Skyy Moore returned the opening kickoff 98 yards and running back Christian McCaffrey got the final yard the Niners needed for a touchdown one play later. That made it 7-0 with 16 seconds off the clock in Arizona.

The San Francisco 49ers face the Arizona Cardinals in Week 11 of the NFL season on Sunday at State Farm Stadium.

This guy Jaxon Smith-Njigba is something else! He leads the league in receiving yards and he shows just why with a sublime one-handed catch down the left sideline to clutch Sam Darnold's floated pass over the top of the defender.

What's the Arizona Cardinals vs San Francisco 49ers score? Follow our live score updates for latest news, highlights, analysis from NFL Week 11 game.

The 49ers quarterback is making his first start since Week 4 and he has his first touchdown pass since returning to action. Purdy hit tight end George Kittle with a 30-yard bomb to give the 49ers a 13-0 lead with 9:51 to play in the first quarter.

The San Francisco 49ers and Arizona Cardinals are two NFL teams that have had rough luck dealing with an avalanche of injuries so far this season.

The 49ers are 3.5-point favorites, according to the latest 49ers vs. Cardinals odds. The over/under for total points scored is 48.5. Before making any 49ers vs. Cardinals picks, make sure you check out the NFL picks from the SportsLine Projection Model.