Drug safety and efficacy are key concerns for manufacturers during the long, complex, and costly drug development process. Regulatory agencies now expect that immune responses caused by drug treatment ...

Anti-idiotypic antibodies (anti-ID Ab) are antibodies that identify and attach to the idiotypic center of other antibodies. Anti-idiotype antibodies are commonly employed in therapeutic drug ...

As cold and flu season ramps up, the most vulnerable among us need extra protection. Infants are among the most susceptible to respiratory complications from respiratory syncytial virus, or RSV. While ...

The Clinical Implications of Basic Research series has focused on highlighting laboratory research that could lead to advances in clinical therapeutics. However, the path between the laboratory and ...

Assessing the safety and efficacy of biotherapeutics is imperative during the drug development process. In particular, pharmacokinetic (PK) and anti-drug antibody (ADA) assays are conducted to study ...

Introducing a range of anti-idiotypic antibodies targeting the immune checkpoint inhibitor drugs pembrolizumab and nivolumab. Anti-pembrolizumab and anti-nivolumab antibodies are designed for use in ...

Flavopiridol, A Novel Cyclin-Dependent Kinase Inhibitor, in Metastatic Renal Cancer: A University of Chicago Phase II Consortium Study PURPOSE: To determine immune responses and toxicity to the ...

Candidacidal KT-mimicking scFvH6 anti-idiotypic antibodies were produced by recombinant DNA technology from the splenic lymphocytes of mice immunized by idiotypic vaccination with a KT-neutralizing ...

With around 256 million cases and more than 5 million deaths worldwide, the COVID-19 pandemic has challenged scientists and those in the medical field. Researchers are working to find effective ...

Multiple myeloma (MM) is a malignant plasma cell disorder derived from a B cell clone. 1 Median survival time of untreated MM patients is less than 1 year. Treatment with alkylating agents induces a ...

Abbreviations: CR, complete response; CRu, unconfirmed complete response; CVP, cyclophosphamide, vincristine, and prednisone; DFS, disease-free survival; NCI ...

Murphy and Longo (published online on Nov. 24 at NEJM.org) 1 elaborate on the possible role played by anti-idiotype antibodies in the pathogenesis of severe adverse reactions to SARS-CoV-2 infection ...