Preview the Oct. 11 matchup between the Clemson Tigers and Boston College Eagles with predictions, odds, over/under, spread, betting lines and more.

Clemson is favored by 14 points against Boston College, per the VegasInsider.com consensus betting line. The point spread has risen slightly since opening at Clemson -12.5 and is the third game in a row the Tigers have been favored by 14-plus.

Bill Belichick’s first Atlantic Coast Conference matchup is against the coach and team that has been the most dominant in the conference over the last decade —

Clemson returns to action against North Carolina in college football’s Week 6 action on Saturday featuring a head coaching matchup of some historical consequenc

Clemson (3-3, 2-2 ACC) has routinely used jumbo packages featuring multiple offensive linemen and defensive linemen on the field in short-yardage or goal-line situations. Occasionally, Swinney and the Tigers will also line up a defensive lineman at running back or fullback and give them carries.

Saturday marks the 33rd meeting between the two programs. Clemson holds a 21-9-2 advantage and has won 12 straight over the Eagles since 2010. The game kicks off at 7:30 p.m. ET from Alumni Stadium and will air on ACC Network, with streaming available on ESPN+ and Fubo.

Cade Klubnik threw for a touchdown and ran for another when Clemson opened a big first-half lead before leaving with an injury late in the third quarter, and the Tigers beat struggling Boston College 41-10.

After missing the start of the season, Khalil Barnes is back and making an impact in Clemson’s secondary, earning high praise from Dabo Swinney.