Trappsol® Cyclo™ is a proprietary, intravenous formulation of 2-hydroxypropyl-β-cyclodextrin in development to treat diseases associated with impaired cholesterol metabolism, including Alzheimer's ...
In people carrying the APOE4 risk variant, a key brain cell type mismanages cholesterol needed to insulate neurons properly --another sign that APOE4 contributes to disease by disrupting lipids in the ...
The APOE4 variant causes cholesterol buildup in the cells that make protective fatty sheaths for neurons, possibly helping explain its role in neurodegeneration. Using transcriptomic profiling, the ...
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