Scientists at CRISPR Therapeutics have compared three commonly used methods to detect off-target gene editing activity of the CRISPR-Cas9 machinery and found them to be equally adept, although each ...
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CRISPR RNA-guided nucleases (RGNs) are widely used genome-editing reagents, but methods to delineate their genome-wide, off-target cleavage activities have been lacking. Here we describe an approach ...
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