The Sunday afternoon slate for Week 9 is headlined by two big AFC matchups with playoff implications. In the early afternoon window, it's two first-place teams facing off when the Indianapolis Colts (7-1) head to Pittsburgh (4-3) for a showdown with the Steelers.

The Bills are 3.5-point favorites, according to the latest Bills vs. Steelers odds. The over/under for total points scored is 44.5. Before making any Bills vs. Steelers picks, make sure you check out the NFL picks from the SportsLine Projection Model.

The Dolphins have four players listed as questionable, including tight end Darren Waller and offensive tackle Austin Jackson, but coach Mike McDaniel said he's optimistic about their chances at joining the lineup.

The San Francisco 49ers and Cleveland Browns meet Sunday for a Week 13 matchup. Kickoff from Huntington Bank Field is scheduled for 1 p.m. ET.

The 4-7 Miami Dolphins are hosting the 2-9 New Orleans Saints at Hard Rock Stadium for a Week 13 AFC vs. NFC matchup that have more relevance for the next NFL Draft as opposed to the upcoming playoffs.