The future of gene editing depends on tools that are programmable, scalable, and adaptable to diverse disease contexts. Recombinases are emerging as a promising solution, but optimizing their ...

Recombinase-mediated cassette exchange (RMCE) is a powerful tool for the modification of the Drosophila genome and its utility has now been extended through the use of another site-specific ...

During infection, the human immunodeficiency virus (HIV) inserts itself into the host genome as a chromosomally-integrated provirus that persists in infected cells. Although antiretroviral therapies ...

For decades, gene-editing science has been limited to making small, precise edits to human DNA, akin to correcting typos in the genetic code. Arc Institute researchers are changing that paradigm with ...

Dresden, Hamburg. Researchers at the Medical Faculty of the Technische Universität Dresden (TUD) and the Heinrich Pette Institute (HPI), Leibniz Institute for Experimental Virology succeeded in ...

A research team presents a noninvasive light-sensitive photoactivatable recombinase suitable for genetic manipulation in vivo. The highly light-sensitive property of photoactivatable Flp recombinase ...

A rapid isothermal amplification technique enables pathogen identification and antibiotic resistance detection in low-resource settings. Recombinase polymerase amplification (RPA) is a technique for ...

A team of researchers at the Carl Gustav Carus Faculty of Medicine, TUD Dresden University of Technology, led by Prof. Frank Buchholz, has achieved a major breakthrough in genome editing technology.

A new molecule, photoactive Flp recombinase, has been developed for use in an optogenetic technique that can deliver non-invasive genetic manipulation in the deep brain tissue of mice. A research team ...

A team of Chinese researchers led by Prof. GAO Caixia from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences has developed two new genome editing technologies, ...

Researchers have succeeded in developing a designer recombinase (Brec1) that is capable of specifically removing the provirus from infected cells of most primary HIV-1 isolates. Researchers at the ...