The matchup is going to be tough despite being a home game. San Francisco quarterback Brock Purdy is finally set to return on Sunday. With their main man back under center, the 49ers are sure to adjust offensive strategies compared to last time they faced the Cardinals, when Mac Jones handled the duties.

The Arizona Cardinals had their top running back questionable entering Sunday's tilt against the San Francisco 49ers.

Knight (ankle) is listed as questionable for Sunday's game against the 49ers, Darren Urban of the Cardinals ' official site reports.

Start em or sit em? Fantasy football start or sit decisions can be excruciating. While it feels great to make the right call and cruise to fantasy glory, it hurts just as much when you have someone erupt while on

An injured Kyler Murray, a depleted backfield and really, inconsistent football. It didn’t stop today either in their loss to the San Francisco 49ers in Week 11. Let’s take a look at some key stats that led to the Cardinals' seventh loss of the season:

Knight, who is listed as questionable for Sunday's Week 11 contest versus San Francisco due to an ankle injury, is expected to play, Adam Schefter of ESPN reports.