Sen. Lisa Murkowski is opposing the nomination of Pete Hegseth to be President Donald Trump's Defense secretary.

Sen. Lisa Murkowski (R-AK) announced “she cannot in good conscience” support Pete Hegseth’s nomination for Defense Secretary on Thursday, making her the first Republican senator to announce opposition to his nomination.

The Alaska Republican plans to vote against the confirmation of Pete Hegseth to lead the Department of Defense.

Some GOP senators want public commitments from Robert F. Kennedy Jr. before deciding whether to support him as the next secretary of the Department of Health and Human Services, signaling that President Donald Trump’s pick will have to win over uncertain Republicans in order to secure the job.

Republican Alaska Sen. Lisa Murkowski — who broke with her party on numerous occasions to support former President Joe Biden’s

Even as handicappers adjudged Pete Hegseth ’s confirmation as secretary of Defense to be all but certain, not one but two Republican senators indicated a hard pass on the poorly qualified bad boy from Fox News.

Most of President Donald Trump's successful Cabinet nominees so far — including, as of Monday evening, Treasury Secretary Scott Bessent — were confirmed by comfortable margins. But Defense Secretary Pete Hegseth squeaked by 51 to 50, with Vice President J.D. Vance casting the second-ever tie-breaking vote for a Cabinet secretary.

Moderate GOP Sen. Lisa Murkowski of Alaska has broken her silence, saying she won't be voting to confirm Pete Hegseth as secretary of defense.

Sen. Murkowski is now the third most senior Republican member of the Senate Appropriations Committee, and when Kentucky Republican Sen. Mitch McConnell retires at the end of 2026, she will be the second most senior Republican member.

During a confirmation hearing for Robert F. Kennedy Jr., President Donald Trump's nominee for health secretary, Alaska U.S. Sen. Lisa Murkowski on Thursday urged Kennedy to use his platform to boost public confidence in vaccines but did not indicate whether she would support his nomination.

Kennedy’s bid to serve as America’s top health official may be decided by a handful of Republicans, including several senators who questioned him Thursday.