Perturbations in intracellular Ca homeostasis, produced by Pb at low concentrations, may be an unifying hypothesis to explain Pb toxicity at the cellular level. Such perturbations may place the ...

Precise Ca cycling through the sarcoplasmic reticulum (SR), a Ca storage organelle, is critical for proper cardiac muscle function. This cycling initially involves SR release of Ca via the ryanodine ...

Diabetes. 2007;56(6):1489-1501. Under overnight fasting conditions, endogenous hepatic (and renal) glucose production is balanced by basal glucose utilization by brain (50% of total) and other tissues ...

Taking out the garbage is a crucial step in housecleaning. Similarly, autophagy is the body’s first-line of defense against the buildup up of toxic substances, degrading old organelles and proteins to ...

Diabetes. 2007;56(6):1489-1501. It is a truism that obesity is increasing in the U.S. and other Western countries and is also increasing in less well-developed nations. [87] Obesity is an important ...