San Francisco 49ers QB Brock Purdy dispensed with questions over his health and simultaneously silenced debate over Mac Jones ...

The 49ers' team captains stepped up in Arizona. One of them, George Kittle, said the team is positioned right where it needs ...

On a 70-yard, first-quarter drive that made the score 13-0, the 49ers needed only five plays to reach the end zone with three ...

Jacoby Brissett completed an NFL-record 47 passes, but San Francisco's offense rolled in Purdy's first game in weeks.

Kickoff from State Farm Stadium is set for 4:25 p.m. ET on FOX. The 49ers are 3.5-point favorites, according to the latest ...

Winston DeLattiboudere turns 28 in January and was a college teammate for two of his five seasons as a player at the ...

San Francisco 49ers running back Christian McCaffrey rushes for a 12-yard gain against the Arizona Cardinals. Cleveland ...

Arizona Cardinals linebacker Josh Sweat logs the first sack of the game in the third quarter, taking down San Francisco 49ers quarterback Brock Purdy for a 14-yard loss.