A research group has demonstrated that overexpression of Cdc10-dependent transcript 1 (CDT1), a key regulator of DNA ...

New research published in Nature Communications has linked a normal cellular process to an accumulation of DNA mutations in ...

Highlighting 10 innovative late-stage BioPharma drugs with the potential to reshape treatment paradigms and industry dynamics. Click here to read our picks.

Traditional drug research has focused on creating inhibitors that occupy the active areas of disease-related proteins, preventing them from functioning properly. But this strategy leaves a ...

The discovery of DNA ligase by the Gellert, Lehman, Richardson, and Hurwitz teams in 1967 was a breakthrough in molecular biology. These essential enzymes maintain genome integrity and play a vital ...

If these DNA breaks aren't repaired, they can prompt cells to self-destruct, or failing that, become cancerous. As LIG4 syndrome impairs this response, people with the condition are particularly ...

Police have arrested an 83-year-old man in connection to a cold case involving the murder of an elderly woman in Dallas more than 40 years ago thanks to a DNA match. On Monday, Dallas Police announced ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 9 (March 1, 2022), pp. 1-7 (7 pages) The mitotic (or spindle assembly) checkpoint system ensures accurate ...

Department of Urology, The First Affiliated Hospital of Ningbo University, Ningbo University, Ningbo, Zhejiang, China Renal cell carcinoma (RCC) is a malignant tumor of the renal tubular epithelial ...