Microbiologists have long known that ancient, inactive viruses known as cryptic prophages can insert their genetic material into bacterial DNA. These genetic fragments allow bacteria to use ...

Fixing the balance of a single brain circuit erased anxiety and social deficits in mice, revealing a powerful new target for ...

Cpf1-endo-recombinase CauR co-edited platform was developed and successfully applied to the glutamate-producing strain ...

Corynebacterium glutamicum S9114, a superior strain widely used in glutamic acid industrial production through traditional mutagenesis screening, is ...

During infection, the human immunodeficiency virus (HIV) inserts itself into the host genome as a chromosomally-integrated provirus that persists in infected cells. Although antiretroviral therapies ...

Nerve fibers in the brain and spinal cord are wrapped in an insulating sheath known as myelin. For a long time, this barrier, which is essentially the brain's white matter, was believed to serve the ...

Abstract: An important challenge in synthetic biology is the construction of periodic circuits with tunable and predictable period. We propose a general architecture, based on the use of recombinase ...

This study offers important insight into the pathogenic basis of intragenic frameshift deletions in the carboxy-terminal domain of MECP2, which account for some Rett syndrome cases, yet similar ...

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directionality: reversible or not recombination enzyme used recombination sequence used number of DNA molecules present in the reaction and number of recombination sites in each molecule purpose: ...