Full-strength offense explodes, showcasing dominant Purdy, McCaffrey, and Kittle. Niners dominate, extending their bizarre odd-week winning streak.

The University of the Pacific and the San Francisco 49ers entered a partnership on Friday. Here's what that means.

Head coach Kyle Shanahan of the San Francisco 49ers looks on during warmups before the game against the Arizona Cardinals at State Farm Stadium on Nov. 16, 2025 in Glendale, Ariz. A costly penalty by a San Francisco 49ers defensive player led head coach Kyle Shanahan to bench him and confront him on the sidelines.

The San Francisco 49ers did something in Week 11 that they hadn’t done since Week 5. They took a lead in the first quarter. The offense took the field at the two-yard line after a 98-yard kickoff return by Skyy Moore. Christian McCaffrey punched it in ...

The Arizona Cardinals and San Francisco 49ers revealed their final inactives report for Week 11 - who's in, who's out?

Follow along with live updates as the San Francisco 49ers begin a crucial four-game stretch starting in Arizona against the Cardinals.

The San Francisco 49ers open the game with a 98-yard kick return and running back Christian McCaffrey caps off the drive on the first play with a 1-yard rushing touchdown on the road against the Arizona Cardinals in the first 13 seconds of the game.