Prior to Saturday night’s loss to the Johnnies in the Big East Final, the Bluejays had won three in a row. Ryan Kalkbrenner leads the team nightly in scoring (19.4) and rebounding (8.8). Steven Ashworth directs the offense from the point averaging 6.8 assists per game.

It’s Louisville Cardinals vs Creighton Bluejays to begin March Madness. Here’s our prediction for the 2025 NCAA Tournament basketball game.

The first full day of March Madness begins as we continue our College Basketball odds series with a Creighton-Louisville prediction and pick.