The San Fransico 49ers travel to the desert to take on the Las Vegas Raiders in Game 2 of the 2025 NFL preseason for both teams. The 49ers are fresh off a 30-9 shellacking by the Denver Broncos in the first preseason game on Aug.

For the 49ers their health has become a greater concern than their preseason performance. They just need to make sure they have enough healthy bodies to keep their key starters out of harm's way. More than 20 players missed their preseason opener vs. the Denver Broncos with injuries, and that number could rise Saturday when they face the Raiders.

The second preseason game versus the Las Vegas Raiders was more entertaining for the San Francisco 49ers than the first. Part of that is because the starters got a bit of action, but it's also because the 49ers had some players stand out.

Raiders rookie Ashton Jeanty proved he could deliver hits and absorb them at the NFL level. He rushed for a bruising 33 yards and a touchdown on seven carries in Las Vegas’ 22-19 preseason loss to the San Francisco 49ers on Saturday.

The Las Vegas Raiders suffered a dramatic loss last Saturday to their old rivals from the Bay, the San Francisco 49ers. While the results will be washed away with the beginning of the regular season, the lessons learned in the preseason will predict the strength of their roster.

Raiders head coach Pete Carroll has high praise for this crucial acquisition from the offseason after the loss to the 49ers.