The San Francisco 49ers had huge plays on both sides of the ball to earn a blowout win over the Arizona Cardinals. Here are the highlights.

Glendale, AZ -- The 49ers just blew out the Arizona Cardinals 41-22. Granted, the Cardinals got blown out last week too and now have lost 7 of their past 8 games since they lost to Mac Jones and the 49ers in Week 3. They're dead. They need to fire their head coach.

The Cardinals quarterback completed 47 passes against the San Francisco 49ers — a new NFL record. Brissett went 47-of-57 for 452 yards, two touchdowns and two interceptions. The 49ers, though, were too much for the Cardinals as they fell,

The San Francisco 49ers (6-4) visit the Arizona Cardinals (3-6) Sunday in Week 11. Kickoff from State Farm Stadium in Glendale, Arizona, is at 4:05 p.m. ET (FOX). Let's analyze BetMGM Sportsbook's NFL odds around the 49ers vs. Cardinals odds and make our expert NFL picks and predictions for the best bets.

Sweat had another sack for the Cardinals to push his season total to nine. The rest of the defense has combined for ten, so he’s very literally carrying this pass rush. Given he’s still under 30 years old, he is the future of this pass rush for years to come.

The 49ers are 3.5-point favorites, according to the latest 49ers vs. Cardinals odds. The over/under for total points scored is 48.5. Before making any 49ers vs. Cardinals picks, make sure you check out the NFL picks from the SportsLine Projection Model.