Expert recap and game analysis of the San Francisco 49ers vs. Arizona Cardinals NFL game from November 16, 2025 on ESPN.

San Francisco 49ers running back Christian McCaffrey scores his third touchdown of the game against the Arizona Cardinals ...

Arizona had the passing game working, but it didn't matter in a 41-22 loss to San Francisco at State Farm Stadium in Glendale ...

I don’t know any other running backs that can do that, to be honest,” Brock Purdy said of Christian McCaffrey’s touchdown ...

During a late Sunday afternoon window with three exciting football games, the 49ers and Cardinals played a dull one.

» Not only did the Niners’ tight end catch a touchdown of his own, but he was instrumental on the 49ers’ third touchdown of ...

Brock Purdy's return went as well as the San Francisco 49ers could have hoped, as they routed the Arizona Cardinals on Sunday ...

Brock Purdy returned from a six-game absence to throw three touchdowns as the 49ers (7-4) romped to a 41-22 win over the host ...

Brock Purdy lanzó tres pases de touchdown en su regreso tras una lesión en el dedo del pie, Christian McCaffrey anotó dos ...

Brock Purdy passed for 200 yards and three touchdowns in his first game since Sept. 28, Christian McCaffrey scored three ...

Josh Allen threw for three touchdowns and rushed for three more, the last on a rugged 9-yard run with 2:35 left that secured ...