Brock Purdy threw three touchdown passes in his return from a toe injury, Christian McCaffrey had two rushing touchdowns and ...

San Francisco 49ers running back Christian McCaffrey scores his third touchdown of the game against the Arizona Cardinals ...

Arizona had the passing game working, but it didn't matter in a 41-22 loss to San Francisco at State Farm Stadium in Glendale ...

San Francisco 49ers running back Christian McCaffrey rushes for a 12-yard gain against the Arizona Cardinals. Cleveland ...

I don’t know any other running backs that can do that, to be honest,” Brock Purdy said of Christian McCaffrey’s touchdown ...

The offense put pressure on the Cardinals time and time again, and that was the difference in the 49ers blowout win.

During a late Sunday afternoon window with three exciting football games, the 49ers and Cardinals played a dull one.

» Not only did the Niners’ tight end catch a touchdown of his own, but he was instrumental on the 49ers’ third touchdown of ...

Wide receiver Skyy Moore returned the opening kickoff 98 yards and running back Christian McCaffrey got the final yard the ...

Brock Purdy returned from a six-game absence to throw three touchdowns as the 49ers (7-4) romped to a 41-22 win over the host ...

The Arizona Cardinals take on the San Francisco 49ers on Sunday at State Farm Stadium, kicking off at 4:05 p.m. ET (2:05 p.m.