Brock Purdy threw three touchdown passes in his return from a toe injury, Christian McCaffrey had two rushing touchdowns and ...

San Francisco 49ers running back Christian McCaffrey scores his third touchdown of the game against the Arizona Cardinals ...

Arizona had the passing game working, but it didn't matter in a 41-22 loss to San Francisco at State Farm Stadium in Glendale ...

San Francisco 49ers running back Christian McCaffrey rushes for a 12-yard gain against the Arizona Cardinals. Cleveland ...

I don’t know any other running backs that can do that, to be honest,” Brock Purdy said of Christian McCaffrey’s touchdown ...

The offense put pressure on the Cardinals time and time again, and that was the difference in the 49ers blowout win.

What's the Arizona Cardinals vs San Francisco 49ers score? Follow our live score updates for latest news, highlights, ...

» Not only did the Niners’ tight end catch a touchdown of his own, but he was instrumental on the 49ers’ third touchdown of ...

Brock Purdy's return went as well as the San Francisco 49ers could have hoped, as they routed the Arizona Cardinals on Sunday ...

Wide receiver Skyy Moore returned the opening kickoff 98 yards and running back Christian McCaffrey got the final yard the ...

Learn more about for Christian McCaffrey's prop betting lines, stats and more before his San Francisco 49ers play against the ...

The 49ers have stayed competitive after a wave of injuries. But Sunday's loss showed they can't match the league's top teams ...