A backup quarterback made NFL history Sunday with a clinical performance that set a new single-game completion record. Arizona Cardinals QB Jacoby ...

Brock Purdy had barely settled into his first game back from a toe injury when he checked the opposing defense, made a quick switch at the line of scrimmage and then hit tight end George Kittle for a ...

The San Francisco 49ers blew out the Arizona Cardinals, but there was a lot happening in the Week 11 matchup. Here are the ...

Head coach Kyle Shanahan of the San Francisco 49ers looks on during warmups before the game against the Arizona Cardinals at ...

Sweat had another sack for the Cardinals to push his season total to nine. The rest of the defense has combined for ten, so ...

Brock Purdy threw three touchdown passes in his return from a toe injury, Christian McCaffrey had two rushing touchdowns and ...

The San Francisco 49ers dominated their Week 11 matchup as the Arizona Cardinals were exposed once again.

The Arizona Cardinals set a franchise record with 17 penalties during their latest loss, a 41-22 disaster vs. the 49ers, and ...

After a frustrating six-week absence because of an injury, San Francisco 49ers quarterback Brock Purdy didn't take long to ...

The most notable is the team franchise record set by the Cardinals for most penalties, with 17 for a total of 130 yards, ...

Detroit Lions middle linebacker Alex Anzalone takes down Philadelphia Eagles running back Saquon Barkley for a loss of 10 ...

The Cardinals have now lost seven of their last eight, including two straight blowouts to divisional opponents.